Laser phase plate boosts cryo-EM image quality for proteins
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Two research teams have developed laser phase plate systems that improve image quality in cryo-electron microscopy, enabling high-resolution structures for a broader range of proteins. The technology addresses a long-standing limitation in the field, potentially accelerating drug discovery and structural biology studies.
The Technology
The laser phase plate systems, developed independently by two teams, enhance contrast in cryo-electron microscopy by altering the phase of electron waves. This allows visualization of proteins that were previously difficult to image, such as those with low molecular weight or in dynamic states. The innovation builds on decades of work to overcome limitations of traditional phase plates.
Research Impact
In tests, the new systems produced structures with resolutions below 3 angstroms for several challenging proteins, including membrane proteins and complexes. One team achieved a 2.8-angstrom resolution for a 150-kilodalton protein, a feat previously unattainable with conventional methods. The results were published in Nature on 12 June 2026.
What's Next
The teams plan to refine the laser phase plate for routine use in cryo-EM facilities. It remains unclear how quickly the technology will be adopted commercially and whether it can be integrated into existing microscopes without major modifications.
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Laser phase plate boosts cryo-EM image quality for proteins
